Abstract Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases.Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca2+ influx across the sarcolemma that causes mitochondrial Ca2+ overload, organelle rupture, and muscle necrosis.The mitochondrial Ca2+ uniporter (MCU)
Apartheid texas rangers pumpkin stencil left South African city regions with two major challenges: social integration at a city level and spatial integration at a regional level.The task to finds solutions to these problems was left to municipalities, the lowest level of the three trier government system introduced after 1994.This article criticall
Magnetohydrodynamic wave phenomena have been investigated in the deep plasmasphere by the electric field measurements in the EXOS-D(Akebono) satellite.EXOS-D has highly eccentric orbits(the perigee: 274km, the apogee: 10,500km), which allows relatively long observational time interval near the apogee pr30 region compared to othe satellites which pa
Patients with immunodeficiencies and older age are at an increased risk of anal cancer.Transgenic K14E6/E7 mice with established high-grade anal dysplasia were treated topically at the anus tashi bharucha with the protease inhibitor saquinavir (SQV) in the setting of CD4+ T-cell depletion to mimic immunodeficiency.To ensure tumor development, speci